Through seven games, Downs was without question the Bears' best player. He has been named the Pac-12 Defensive Player of the Week twice this season and leads the team in tackles (65), interceptions (2), sacks (3), forced fumbles (2) and fumble recoveries (2).
"Really feel for Devante because the guy's been a warrior and worked extremely hard," coach Justin Wilcox said. "So you really feel for him. These are hard and never easy and it's something that he'll bounce back from, but it's tough right now."
Wilcox said it will be a group effort to replace him.
Cal (4-3, 1-3 Pac-12) hosts Arizona (4-2, 2-1) on Saturday.