Hand suffered a strained MCL against Ole Miss last weekend.
Saban said that Hand has not practiced since suffering the injury. A senior from Woodbridge, Virginia, he has 11 tackles and one sack in five games this season.
Saban also said Trevon Diggs, a backup cornerback and lead punt returner, will also miss the game at Texas A&M. Diggs is dealing with a foot injury he suffered against Ole Miss.
When Diggs was sidelined last Saturday, freshman Henry Ruggs III served as his replacement in the return game.